Chronic disabilities caused by pathology to brain and spinal cord deprive millions of people of independence every year. Disorders like Amyotrophic Lateral Sclerosis (ALS) constrain daily function with few, if any, options to restore function. Many ALS patients become paralyzed and locked-in (Locked-In Syndrome, LIS) with little or no way to communicate. However, promising neurotechnological developments make it possible to record and interpret brain signals and translate them to control brain-computer interface (BCI) devices. NeuroTech-NL scientists accomplished a world-first breakthrough in implementing a BCI implant solution for basic communication in an ALS patient with LIS. Now we aim to significantly advance BCI-based communication by extracting and decoding spatially detailed information from the brain and utilizing these neural signals to drive a communication device in a fast and intuitive manner.